Selective abdominal venous congestion to investigate cardiorenal interactions in a rat model
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Key result
Permanent surgical constriction of the thoracic inferior vena cava in adult rats significantly increased abdominal venous pressure (13.8 vs 4.9 mmHg) and induced abdominal venous congestion.
Why the study?
Does constriction of the thoracic IVC induce abdominal venous congestion and cardiorenal interactions in a rat model?
Population
20 male healthy Sprague-Dawley rats (6 ± 1 weeks, 135 ± 15g)
Comparison
Permanent surgical constriction of the thoracic… vs Sham-operated rats subjected to the same…
Design
Preclinical, randomly divided into two groups
Follow-up
12 weeks
Authors
Discussion
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Implication
Supports a novel rat model for abdominal venous congestion; leaves open translation to human cardiorenal syndrome.
Structured PICO
Does constriction of the thoracic IVC induce abdominal venous congestion and cardiorenal interactions in a rat model?
P
Population
20 male Sprague-Dawley rats (6 weeks old) randomized to permanent surgical constriction of the thoracic inferior vena cava or sham operation, followed for 12 weeks.
I
Intervention
Permanent surgical constriction of the thoracic inferior vena cava (IVC) using a 20 gauge needle
C
Comparator
Sham-operated rats subjected to the same surgical procedure without application of the constriction
O
Outcome
Development of abdominal venous congestion (abdominal venous pressure) and renal/cardiac function parameters at 12 weekssurrogate
Main Result
Absolute Event Rate: 13.8% vs 4.9%
p-value: p=<0.01
Constriction of the thoracic IVC in rats successfully induces abdominal venous congestion and renal dysfunction without compromising cardiac output, providing a novel model for studying cardiorenal syndrome.
Limitations
- Isoflurane anesthesia was applied, which may have dose-dependent effects on cardiac hemodynamics.
- Lack of evaluation of the GFR with an exogenous tracer such as inulin.
- The magnitude of constriction cannot be determined because the original IVC diameter may vary between rats and was not measured.
- Only male rats were used, excluding effects from the female reproductive system.
- High mortality rate (50%) due to complications such as bleeding and pneumothorax.
- High mortality rate (50%) for the IVC constriction surgery
Cite This Study
Cops et al. (2018) studied Healthy (to induce abdominal venous congestion) (n=20). Permanent surgical constriction of the thoracic inferior vena cava vs. Sham operation was evaluated on Abdominal venous pressure (p=<0.01). Permanent surgical constriction of the thoracic inferior vena cava in adult rats significantly increased abdominal venous pressure (13.8 vs 4.9 mmHg) and induced abdominal venous congestion.
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