Key result
Chronic renal venous pressure elevation in rats attenuated the drop in renal blood flow upon further pressure increase at 3 weeks (-1.5 vs -4.2 mL/min, P<0.05).
Why the study?
Acutely increased renal venous pressure impairs renal function, but its long-term impact on baseline renal function and cardiovascular stability during further pressure increases is unknown.
Does chronic renal venous pressure elevation modulate renal function and cardiovascular stability in rats?
Population
Rats (n = 17 at 1 wk, n = 22 at 3 wk)
Comparison
Renal venous pressure elevation (20–25 mmHg) vs sham operation
Design
Animal experimental study
Follow-up
1 wk or 3 wk
Authors
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Chronic RVP elevation may induce protective adaptations in rats; leaves open relevance to human cardiorenal syndromes.
Does chronic renal venous pressure elevation modulate renal function and cardiovascular stability in rats?
Absolute Event Rate: -1.5% vs -4.2%
p-value: p=<0.05
Chronic elevation of renal venous pressure in rats induces protective adaptations, including venous collateral formation, that attenuate hemodynamic compromise during further pressure increases.
Hamza et al. (2020) studied Healthy rats (n=39). Renal venous pressure (RVP) elevation vs. Sham operation was evaluated on Drop in renal blood flow (RBF) upon further RVP increase at 3 weeks (p=<0.05). Chronic renal venous pressure elevation in rats attenuated the drop in renal blood flow upon further pressure increase at 3 weeks (-1.5 vs -4.2 mL/min, P<0.05).
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