Population
Pentobarbital-anesthetized dogs
Comparison
Gradual elevation of renal venous pressure (RVP) vs Baseline or lower RVP levels (up to 30 mmHg)
Design
Preclinical
Authors
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Renal venous pressure thresholds may inform cardiorenal models; leaves open translation to human venous congestion and renin-driven therapies.
Renal venous pressure elevation increases renin secretion rate independently of changes in renal blood flow, GFR, or sodium excretion, likely via an intrarenal baroreceptor mechanism.
Kishimoto et al. (1972) studied this question.
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