Why the study?
Does increased plasma oncotic pressure via hyperoncotic dextran or albumin infusion alter renal hemodynamics and renin release in anesthetized dogs?
Population
Dogs anesthetized with sodium pentobarbital
Design
Preclinical
Authors
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May alter renin release via tubular mechanisms in dogs; leaves open human relevance and baroreceptor vs tubular autoregulation.
Does increased plasma oncotic pressure via hyperoncotic dextran or albumin infusion alter renal hemodynamics and renin release in anesthetized dogs?
Increased plasma oncotic pressure induces renal vasodilation and increased renin release, suggesting a tubular autoregulatory mechanism rather than a renal baroreceptor mechanism.
Hall et al. (1976) studied this question.
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