Key result
Amlodipine significantly decreased exercise-induced platelet activation compared with placebo in patients with chronic stable angina.
Why the study?
Does amlodipine reduce exercise-induced platelet activation in patients with chronic stable angina?
Population
20 patients with chronic stable angina
Comparison
Amlodipine 10 mg/day for 4 weeks vs Placebo for 4 weeks
Design
RCT, randomized into two groups of 10 patients each
Follow-up
4 weeks
Authors
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May attenuate exercise-related thrombotic risk in stable angina; extends amlodipine effects beyond vasodilation.
RCT (n=20)
randomized
Does amlodipine reduce exercise-induced platelet activation in patients with chronic stable angina?
Amlodipine 10 mg/day significantly reduces exercise-induced platelet activation in patients with chronic stable angina.
Sanguigni et al. (1999) conducted an RCT in chronic stable angina (n=20). amlodipine vs. placebo was evaluated on exercise-induced platelet activation (GMP-140 expression). Amlodipine significantly decreased exercise-induced platelet activation compared with placebo in patients with chronic stable angina.
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