January 1, 1996Psychosomatic Medicine
Effects of Hostility on Platelet Reactivity to Psychological Stress in Coronary Heart Disease Patients and in Healthy Controls
Why the study?
Does a laboratory psychological stressor increase platelet activation, and is this reactivity related to hostility in post-MI patients and healthy men?
Population
14 stable post-MI patients and 15 age-matched healthy men
Comparison
Laboratory stressor (Type A Structured Interview… vs Baseline and comparison between post-MI patients…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Acute stress may heighten platelet reactivity linked to hostility in CHD; leaves open causal role in events and needs prospective confirmation.
Structured PICO
Does a laboratory psychological stressor increase platelet activation, and is this reactivity related to hostility in post-MI patients and healthy men?
P
Population
14 stable post-MI patients and 15 age-matched healthy men
I
Intervention
Laboratory stressor (Type A Structured Interview (SI) and speech task)
C
Comparator
Baseline (pre-stressor) and comparison between post-MI patients and healthy controls
O
Outcome
Platelet activation measured by plasma beta-thromboglobulin (BTG) levelssurrogate
Acute psychological stress increases platelet activation, and this reactivity is strongly associated with hostility traits, independent of prior platelet inhibitor use.
Cite This Study
Markovitz et al. (1996) studied this question.