Why the study?
Do active and passive stressors increase platelet activation in healthy men?
Do active and passive stressors increase platelet activation in healthy men?
Psychological stress, whether active or passive, directly increases platelet activation in healthy men, which may have implications for the pathogenesis of coronary artery disease.
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May link psychological stress to CAD via platelets; hypothesis-generating and should not yet change practice.
Blood platelets have been found to play a major role in the pathogenesis of coronary artery disease. This study examined the effects of active and passive stressors on platelet function and assessed the possible effects of perceived control on platelet reactivity to stress. Heart rate, blood pressure, catecholamine levels, and platelet factor 4 (PF 4) were assessed in 55 healthy males during resting baseline (25 min), 7-min stressor/task periods, and recovery (60 min). Results showed significant increases in PF 4 during the stressor/task periods for both active and passive stressor groups. Psychological stress involving both active and passive participation had a direct effect on platelet activation.
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Patterson et al. (1994) studied this question.
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