Population
Transgenic mice overexpressing a fusion gene of mouse transthyretin regulatory and atrial natriuretic factor…
Comparison
Acute blood volume expansion vs Non-transgenic littermates
Design
Preclinical
Authors
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Suggests ANF overexpression augments renal excretory responses in mice; hypothesis-generating and requires human validation before clinical consideration.
Transgenic mice overexpressing ANF exhibit enhanced diuretic and natriuretic responses to acute blood volume expansion, suggesting that an increase in pressure allows full renal expression of chronically elevated ANF.
Field et al. (1991) studied this question.
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