Key result
Chronically elevated atrial natriuretic factor (ANF) concentrations in transgenic mice induced sustained hypotension, with mean arterial blood pressure inversely proportional to hepatic ANF expression.
Why the study?
Does chronic elevation of ANF induce sustained hypotension in transgenic mice?
Population
Transgenic mice harboring either mouse transthyretin or rat phosphoenolpyruvate carboxykinase promoters…
Design
Preclinical
Authors
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Animal model of chronic ANF elevation enables study of sustained effects; leaves open clinical translation.
Does chronic elevation of ANF induce sustained hypotension in transgenic mice?
Transgenic mouse models demonstrate that chronically elevated atrial natriuretic factor (ANF) concentrations can induce sustained hypotension.
Steinhelper et al. (1991) studied this question. Transgenic expression of ANF gene in the liver was evaluated on Mean arterial blood pressure and hepatic/plasma immunoreactive ANF concentrations. Chronically elevated atrial natriuretic factor (ANF) concentrations in transgenic mice induced sustained hypotension, with mean arterial blood pressure inversely proportional to hepatic ANF expression.
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