Why the study?
Does life-long elevation of plasma ANF alter single-nephron filtration rate and proximal tubular function in mice?
Population
Transgenic mouse model (TTR-ANF) in which atrial natriuretic factor (ANF) expression is targeted to the liver
Comparison
Life-long elevation of plasma ANF concentration vs Nontransgenic siblings
Design
Preclinical
Follow-up
life-long
Authors
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Chronic ANF elevation spares proximal function in mice; leaves open distal compensatory mechanisms.
Does life-long elevation of plasma ANF alter single-nephron filtration rate and proximal tubular function in mice?
Life-long elevation of plasma ANF does not significantly alter proximal tubular function, suggesting compensatory antinatriuretic mechanisms downstream prevent ANF natriuresis.
Sonnenberg et al. (1994) studied this question.
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