Why the study?
Does in vivo blockade of endogenous atrial natriuretic factor (ANF) using an antibody increase blood pressure in normotensive rats with reduced renal mass?
Population
Normotensive, saline-drinking rats with 60% reduced renal mass
Comparison
Atrial natriuretic factor antibody injected… vs Normal rabbit serum or serum from rabbits…
Design
Preclinical
Follow-up
12 days of treatment plus 4-5 days withdrawal
Authors
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Highlights ANF's compensatory role against BP rise in reduced renal mass; hypothesis-generating with no clinical implications yet.
Does in vivo blockade of endogenous atrial natriuretic factor (ANF) using an antibody increase blood pressure in normotensive rats with reduced renal mass?
In a rat model with reduced renal mass, blockade of endogenous atrial natriuretic factor raises blood pressure, suggesting ANF acts to prevent blood pressure elevation.
Pamnani et al. (1988) studied this question.
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