Why the study?
Compound NS5806 was known to potentiate cardiac transient outward K+ current (Ito) in canine cardiomyocytes, but its effects on Ito in other species had yet to be determined.
Does compound NS5806 modulate the Kv4 potassium channel complex differently depending on the presence of distinct β-subunits across species?
Population
Mouse ventricular cardiomyocytes, hiPSC-CMs, canine cardiomyocytes, and co-transfected HEK293 cells
Comparison
NS5806 exposure across different species and auxiliary subunit configurations
Design
Preclinical in vitro laboratory study
Authors
Loading...
Species-specific NS5806 effects on Ito caution against animal-to-human extrapolation; leaves open DPP6-L dependence in human Kv4 channels.
Does compound NS5806 modulate the Kv4 potassium channel complex differently depending on the presence of distinct β-subunits across species?
The pharmacological modulator NS5806 elicits opposite regulatory effects on the Kv4 channel complex across species depending on the presence of the DPP6-L β-subunit.
Zhang et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: