April 1, 2011Journal of Cardiovascular Electrophysiology
Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes
Why the study?
Does NS5806 differentially affect transient outward potassium currents and sodium currents in canine atrial versus ventricular cardiomyocytes?
Population
Canine right atrial and right ventricular wedge preparations, and enzymatically dissociated atrial and…
Comparison
NS5806 (10 μM) vs Absence of NS5806 (control conditions)
Design
Preclinical
Authors
Discussion
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Implication
These canine data should not change practice; hypothesis-generating for chamber-specific antiarrhythmic targeting.
Structured PICO
Does NS5806 differentially affect transient outward potassium currents and sodium currents in canine atrial versus ventricular cardiomyocytes?
P
Population
Canine right atrial and right ventricular wedge preparations, and enzymatically dissociated atrial and ventricular myocytes
I
Intervention
NS5806 (10 μM)
C
Comparator
Absence of NS5806 (control conditions)
O
Outcome
Electrophysiological effects on transient outward potassium current (I(to)) and sodium current (I(Na))surrogate
NS5806 demonstrates chamber-specific electrophysiological effects, prominently augmenting I(to) in ventricles while potently inhibiting I(Na) in atria.
Cite This Study
Calløe et al. (2011) studied this question.