March 1, 2017Physiological ReportsOpen Access

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Itomodulator NS5806

View Full Paper

Ask AI

Bookmark

Why the study?

Does NS5806 differentially affect transient outward potassium current (Ito) in rabbit ventricular versus atrial myocytes?

Population

Rabbit ventricular and atrial myocytes

Comparison

NS5806 (Ito modulator) vs Flecainide and baseline

Design

Preclinical

Authors

HCHongwei ChengUniversity of Bristol MCMark B. CannellElectrophysiology JHJules C. HancoxElectrophysiology

Discussion

Member takes

Implication

NS5806 differentially modulates Ito and APD in rabbit atria versus ventricles; leaves open translation to human arrhythmia models.

Structured PICO

Does NS5806 differentially affect transient outward potassium current (Ito) in rabbit ventricular versus atrial myocytes?

Population

Rabbit ventricular and atrial myocytes

Intervention

NS5806 (Ito modulator)

Comparator

Flecainide and baseline

Outcome

Transient outward potassium current (Ito) and action potential duration (APD)surrogate

NS5806 exhibits differential, region-specific effects on cardiac transient outward potassium currents, acting as a mixed activator/inhibitor in ventricular myocytes and an inhibitor in atrial myocytes.

Cite This Study

Cheng et al. (2017) studied this question.

synapsesocial.com/papers/6a83e153b0b8dfdc4c62de41 https://doi.org/10.14814/phy2.13172

View Full Paper

Ask AI

Bookmark

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Itomodulator NS5806

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Itomodulator NS5806

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider