African-American Race and Antibodies to Topoisomerase I Are Associated With Increased Severity of Scleroderma Lung Disease

September 1, 1998CHEST JournalOpen Access

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to determine the independent association of African-American race with lung disease severity in scleroderma.
Conducted a retrospective review of 101 patients with diffuse cutaneous scleroderma
Lung function was evaluated using percent predicted values for FVC, DCO, and FEV1
Serum samples were analyzed for antibodies to topoisomerase I and RNA polymerase II.
African-American patients showed significantly lower FVC, DCO, and FEV1 compared to white patients (p<0.0001)
Topoisomerase I antibodies were significantly associated with lower lung function metrics (FVC and DCO)
African-American race and topoisomerase I antibody presence were independent predictors of lower lung function.

We only have this paper's title and publication details.

Answers are grounded in this paper and cite their sources.

Retrospective review assesses lung function differences in scleroderma based on race and autoantibodies, suggesting implications for patient care.

No takes yet. Share an insight, caveat, or question.

Greidinger et al. (1998) studied this question.

View Full Paper

Ask AI

Bookmark

Share