Why the study?
Does lisinopril improve arterial distensibility compared to metoprolol in patients with essential hypertension?
Population
40 patients with essential hypertension
Comparison
Lisinopril (5, 10, or 20 mg) for 10 weeks vs Metoprolol (50, 100, or 200 mg) for 10 weeks
Design
RCT, randomized, double-blind
Follow-up
10 weeks
Authors
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Favors ACE inhibitors over beta-blockers for arterial distensibility in hypertension; confirms pressure-independent vascular effects.
Does lisinopril improve arterial distensibility compared to metoprolol in patients with essential hypertension?
Lisinopril, but not metoprolol, improves arterial distensibility in patients with essential hypertension, suggesting pressure-independent effects of ACE inhibitors on the arterial wall.
Barenbrock et al. (1994) studied this question.
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