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Case reports reveal intracranial bleeding linked to urokinase therapy in acute stroke patients, suggesting risks involved.
Four patients undergoing urokinase infusion therapy for acute occlusive cerebrovascular disease had intracerebral hemorrhage in the ischemic hemisphere. Three patients died during the acute phase of their illness and an autopsy was performed on two. The pathogenesis of cerebral bleeding in these case reports is discussed.
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Hanaway et al. (1976) studied this question.
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