What question did this study set out to answer?

This research aims to develop an animal model to study the induction of paroxysmal atrial fibrillation and its associated heart rate changes.

May 1, 2002Cardiovascular ResearchOpen Access

Endovascular stimulation within the left pulmonary artery to induce slowing of heart rate and paroxysmal atrial fibrillation

Q: What is the clinical evidence from this study?

Study design: Other. Population: Paroxysmal atrial fibrillation (n=12). Intervention: Endovascular stimulation within the left pulmonary artery. Primary outcome: Induction of heart rate slowing and paroxysmal atrial fibrillation.

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Key result

Endovascular stimulation of autonomic nerves in the left pulmonary artery induced heart rate slowing followed by paroxysmal atrial fibrillation in a dog model.

Why the study?

Does endovascular stimulation within the left pulmonary artery induce slowing of heart rate and paroxysmal atrial fibrillation in a dog model?

Population

12 dogs, anesthetized with sodium pentobarbital

Design

Preclinical

Authors

BSB J ScherlagUniversity of Oklahoma Health Sciences Center

Discussion

Member takes

Implication

May facilitate mechanistic studies of vagally mediated paroxysmal AF; leaves open human relevance.

Key Points

This research aims to develop an animal model to study the induction of paroxysmal atrial fibrillation and its associated heart rate changes.
Conducted a right thoracotomy in 12 anesthetized dogs to implant a basket electrode catheter in the left pulmonary artery (LPA).
Stimulated the LPA with varying pulse voltages to assess the effects on heart rate and arrhythmias.
Applied autonomic blockade and radiofrequency energy to analyze the mechanisms behind induced atrial fibrillation.
Stimulation in the LPA at 14±7 V induced heart rate slowing and progression to atrial premature depolarizations, atrial tachycardia, and atrial fibrillation at 20±6 V, P=0.002.
Beta-blockade increased voltage threshold for atrial fibrillation induction to 25±10 V, P=0.02.
Local application of radiofrequency energy abolished both heart rate slowing and arrhythmias from LPA stimulation.

Structured PICO

Does endovascular stimulation within the left pulmonary artery induce slowing of heart rate and paroxysmal atrial fibrillation in a dog model?

Population

12 dogs anesthetized with sodium pentobarbital used to create an animal model for paroxysmal atrial fibrillation.

Intervention

Endovascular electrical stimulation within the left pulmonary artery (LPA) using a basket electrode catheter

Outcome

Induction of slow heart rates, atrial premature depolarizations (APDs), atrial tachycardia (AT), and atrial fibrillation (AF)surrogate

Endovascular stimulation of autonomic nerves in the left pulmonary artery in dogs induces bradycardia followed by paroxysmal atrial fibrillation, providing a novel animal model for vagally mediated paroxysmal AF.

Cite This Study

B J Scherlag (2002) studied Paroxysmal atrial fibrillation (n=12). Endovascular stimulation within the left pulmonary artery was evaluated on Induction of heart rate slowing and paroxysmal atrial fibrillation. Endovascular stimulation of autonomic nerves in the left pulmonary artery induced heart rate slowing followed by paroxysmal atrial fibrillation in a dog model.

synapsesocial.com/papers/6a22ba9129c8bdba62cd6629 https://doi.org/10.1016/s0008-6363(02)00239-0

Topics

Atrial fibrillation Persistent AF management AF ablation outcomes Anticoagulation in AF

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Endovascular stimulation within the left pulmonary artery to induce slowing of heart rate and paroxysmal atrial fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Endovascular stimulation within the left pulmonary artery to induce slowing of heart rate and paroxysmal atrial fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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