Key result
The sensitivity of the diabetic heart to ischemic injury depends on diabetes duration and severity, ischemic flow rate, and exogenous fatty acids, with increased vulnerability in prolonged diabetes.
Why the study?
Does diabetes alter the sensitivity of the heart to ischemic injury?
Population
Diabetic heart (clinical and experimental animal models)
Comparison
Ischemia (zero-flow and low-flow) vs Non-diabetic heart
Design
Review
Authors
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May guide cautious risk stratification in prolonged diabetes; leaves open duration-stratified trials.
Does diabetes alter the sensitivity of the heart to ischemic injury?
The sensitivity of the diabetic heart to ischemic injury is variable and depends on the duration and severity of diabetes, ischemic flow rate, and presence of exogenous fatty acids.
D. J. Paulson (1997) conducted a review in Diabetes and ischemic injury. Diabetes vs. Non-diabetic state was evaluated on Sensitivity to ischemic injury. The sensitivity of the diabetic heart to ischemic injury depends on diabetes duration and severity, ischemic flow rate, and exogenous fatty acids, with increased vulnerability in prolonged diabetes.
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