Key result
Alinidine exhibited a weak anti-muscarinic effect on endothelium-dependent vasodilation in isolated dog coronary arteries, proving approximately 100 times less potent than atropine.
Effect estimate: pKB 6.92
Alinidine exhibits a weak anti-muscarinic effect on endothelium-dependent vasodilation in dog coronary arteries and induces vasodilation independent of common autonomic or histaminergic receptors.
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Alinidine's weak anti-muscarinic action in canine arteries warrants no clinical extrapolation; leaves open its relevance to human coronary physiology.
Nakane et al. (1991) studied None (healthy animal tissue). Alinidine vs. Control (no alinidine) and other muscarinic antagonists was evaluated on Inhibition of acetylcholine-induced vasodilation (pKB) (pKB 6.92). Alinidine exhibited a weak anti-muscarinic effect on endothelium-dependent vasodilation in isolated dog coronary arteries, proving approximately 100 times less potent than atropine.
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