Key result
Atropine blocks acetylcholine-induced renal vasoconstriction across doses, while high doses fully prevent vasodilation.
Why the study?
The role of muscarinic receptors in mediating renal vasodilation and vasoconstriction responses to acetylcholine in the presence of indomethacin was unclear.
The renal vasodilator and vasoconstrictor effects of acetylcholine in indomethacin-treated dogs appear to be mediated by two separate types of muscarinic receptors.
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May indicate distinct muscarinic receptor subtypes in canine renal vasculature; leaves open translation to human physiology or therapy.
Yun et al. (1993) studied this question. Acetylcholine and Atropine vs. Control dogs was evaluated on Renal plasma flow (RPF), sodium excretion (UNaV), and glomerular filtration rate (GFR). In indomethacin-treated dogs, atropine prevented renal vasoconstriction by acetylcholine at all doses, while high-dose atropine (600 micrograms/min) completely inhibited renal vasodilation.
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