June 1, 1967Circulation ResearchOpen Access

Role of Acetylcholine in the Renal Vasoconstrictor Response to Sympathetic Nerve Stimulation in the Dog

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Why the study?

Does acetylcholine mediate the renal vasoconstrictor response to sympathetic nerve stimulation in dogs?

Population

Dogs anesthetized with morphine and chloralose

Comparison

Acetylcholine administered into the renal artery… vs Baseline control values or responses without…

Design

Preclinical

Authors

JMJohn C. McGiffUniversity of Tennessee Health Science Center RBRobert B. BurnsJohns Hopkins University MBMarvin R. BlumenthalTexas Tech University

Discussion

Member takes

Implication

Acetylcholine may facilitate norepinephrine release during canine renal sympathetic activity; leaves open any translational relevance to human renal disease.

Structured PICO

Does acetylcholine mediate the renal vasoconstrictor response to sympathetic nerve stimulation in dogs?

Population

Dogs anesthetized with morphine and chloralose

Intervention

Acetylcholine (ACh) administered into the renal artery at doses of 1, 10, 100, and 1000 µg, alone and after pretreatment with various pharmacological agents (atropine, physostigmine, reserpine, phentolamine, guanethidine, hexamethonium, hemicholinium) or during renal nerve stimulation

Comparator

Baseline control values or responses without pharmacological blockade

Outcome

Renal blood flow and renal vasoconstrictor responsesurrogate

Acetylcholine appears to function in the canine kidney to liberate norepinephrine during sympathetic nerve activity, mediating renal vasoconstriction.

Cite This Study

McGiff et al. (1967) studied this question.

synapsesocial.com/papers/6a87f96cb0d802598bf4c901 https://doi.org/10.1161/01.res.20.6.616

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Implication

Acetylcholine may facilitate norepinephrine release during canine renal sympathetic activity; leaves open any translational relevance to human renal disease.

Role of Acetylcholine in the Renal Vasoconstrictor Response to Sympathetic Nerve Stimulation in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Acetylcholine in the Renal Vasoconstrictor Response to Sympathetic Nerve Stimulation in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider