Why the study?
Does intra-renal infusion of acetylcholine, atropine, or physostigmine alter renal hemodynamics and electrolyte excretion in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Acetylcholine, atropine, or physostigmine… vs Right kidney function (intra-subject control)
Design
Preclinical
Authors
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No immediate clinical implications from this dog study; leaves open cholinergic modulation of human renal hemodynamics and innervation.
Does intra-renal infusion of acetylcholine, atropine, or physostigmine alter renal hemodynamics and electrolyte excretion in anesthetized dogs?
Acetylcholine decreases renal arteriolar resistance and inhibits tubular sodium reabsorption, providing indirect evidence that the kidney lacks parasympathetic innervation.
Arthur J. Vander (1964) studied this question.
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