What question did this study set out to answer?

This study aims to evaluate the impact of NG-monomethyl-L-arginine and L-arginine on renal responses to acetylcholine.

June 1, 1990Hypertension

Effects of NG-monomethyl-L-arginine and L-arginine on acetylcholine renal response.

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Why the study?

Does NG-monomethyl-L-arginine inhibit acetylcholine-induced renal vasodilation and diuresis in meclofenamate-treated dogs?

Population

Meclofenamate-treated dogs

Comparison

Intrarenal infusion of NG-monomethyl-L-arginine… vs Basal levels and acetylcholine alone

Design

Preclinical

Authors

VLVicente LaheraGeneral / Preventive / Lipids MSMiguel G. SalomCross-Cutting Cardiology MFM. J. Fiksen-OlsenCross-Cutting Cardiology

Discussion

Member takes

Implication

No immediate clinical implications for hypertension; extends animal evidence for EDRF mediation of renal acetylcholine responses.

Key Points

This study aims to evaluate the impact of NG-monomethyl-L-arginine and L-arginine on renal responses to acetylcholine.
Intrarenal infusions of acetylcholine, NG-monomethyl-L-arginine, and L-arginine were administered in meclofenamate-treated dogs.
Parameters measured included renal blood flow, diuresis, natriuresis, glomerular filtration rate, and mean arterial pressure.
NG-monomethyl-L-arginine significantly inhibited acetylcholine-induced increases in renal blood flow and diuresis.
L-arginine prevented the inhibitory effects of NG-monomethyl-L-arginine on renal vasodilatation and diuresis.
Natriuresis increased significantly despite the inhibition of renal blood flow and diuresis by NG-monomethyl-L-arginine.

Structured PICO

Does NG-monomethyl-L-arginine inhibit acetylcholine-induced renal vasodilation and diuresis in meclofenamate-treated dogs?

Population

Meclofenamate-treated dogs

Intervention

Intrarenal infusion of NG-monomethyl-L-arginine (inhibitor of endothelium-derived relaxing factor formation) and/or L-arginine (precursor), followed by acetylcholine

Comparator

Basal levels and acetylcholine alone

Outcome

Renal blood flow, diuresis, and natriuresissurrogate

The vasodilatory and diuretic responses to intrarenal acetylcholine in meclofenamate-treated dogs are largely dependent on endothelium-derived relaxing factor.

Cite This Study

Lahera et al. (1990) studied this question.

synapsesocial.com/papers/6a199cbe43a2499ce8f652f0 https://doi.org/10.1161/01.hyp.15.6.659

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Effects of NG-monomethyl-L-arginine and L-arginine on acetylcholine renal response.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of NG-monomethyl-L-arginine and L-arginine on acetylcholine renal response.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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