Key result
L-arginine prolongs and L-NG-methylarginine shortens the duration of acetylcholine-induced hypotension in guinea pigs.
Why the study?
The role of L-arginine availability in modulating acetylcholine-induced vasodilatation in vivo was not fully understood.
Does L-arginine availability affect the duration and magnitude of acetylcholine-induced systemic vasodilatation in anesthetized guinea pigs?
Population
Anesthetized guinea pigs
Comparison
L-arginine vs L-NG-methylarginine effects on acetylcholine-induced hypotension
Design
Preclinical experimental study
Authors
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No direct clinical implications; extends preclinical evidence for L-arginine in nitric oxide-mediated vasodilation.
Does L-arginine availability affect the duration and magnitude of acetylcholine-induced systemic vasodilatation in anesthetized guinea pigs?
De novo synthesis of nitric oxide from L-arginine contributes importantly to the duration and magnitude of acetylcholine's hypotensive effect in vivo.
Aisaka et al. (1989) studied Normotensive and hypertensive conditions (in guinea pigs). L-arginine and L-NG-methylarginine was evaluated on Duration and magnitude of the hypotensive response to acetylcholine. L-arginine prolonged and L-NG-methylarginine decreased the duration of the depressor response to acetylcholine in anesthetized guinea pigs, without modifying its magnitude unless blood pressure was elevated.
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