What does this research mean for the field?

The renal vasodilatory and excretory responses to bradykinin are largely dependent on endothelium-derived nitric oxide. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the role of endothelium-derived nitric oxide in bradykinin-induced renal vasodilatory and excretory effects.

March 1, 1991American Journal of HypertensionOpen Access

Mediatory Role of Endothelium-Derived Nitric Oxide in Renal Vasodilatory and Excretory Effects of Bradykinin

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Why the study?

Does endothelium-derived nitric oxide mediate the renal vasodilatory and excretory effects of bradykinin in anesthetized dogs?

Population

Anesthetized dogs treated with 5 mg/kg intravenous bolus meclofenamate

Comparison

Intrarenal infusions of 5 ng/kg/min bradykinin… vs Basal state or LNMMA alone

Design

Preclinical

Authors

VLVicente LaheraGeneral / Preventive / Lipids MSMiguel G. SalomCross-Cutting Cardiology MFM. J. Fiksen-OlsenCross-Cutting Cardiology

Discussion

Member takes

Implication

Supports NO mediation of bradykinin renal effects in dogs; leaves open human translation.

Key Points

To investigate the role of endothelium-derived nitric oxide in bradykinin-induced renal vasodilatory and excretory effects.
Intrarenal infusions of bradykinin administered to meclofenamate-treated dogs (N=5).
Competitive inhibitor of nitric oxide synthesis (LNMMA) was used to assess its effect on renal responses.
L-arginine was administered to evaluate its protective role against LNMMA's effects.
Bradykinin infusion increased renal blood flow, diuresis, natriuresis, and kaliuresis; effects abolished by LNMMA.
LNMMA alone decreased basal renal blood flow significantly.
L-arginine prevented the inhibitory effects of LNMMA on renal responses to bradykinin.

Structured PICO

Does endothelium-derived nitric oxide mediate the renal vasodilatory and excretory effects of bradykinin in anesthetized dogs?

Population

Anesthetized dogs treated with 5 mg/kg intravenous bolus meclofenamate

Intervention

Intrarenal infusions of 5 ng/kg/min bradykinin (BK) alone or with simultaneous intrarenal infusion of NG-monomethyl-L-arginine (LNMMA) or L-arginine

Comparator

Basal state or LNMMA alone

Outcome

Renal blood flow, diuresis, natriuresis, and kaliuresissurrogate

The renal vasodilatory and excretory responses to intrarenal bradykinin are largely dependent on endothelium-derived nitric oxide.

Cite This Study

Lahera et al. (1991) studied this question.

synapsesocial.com/papers/6a1d180d73c56dd1bd2f281a https://doi.org/10.1093/ajh/4.3.260

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Mediatory Role of Endothelium-Derived Nitric Oxide in Renal Vasodilatory and Excretory Effects of Bradykinin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Mediatory Role of Endothelium-Derived Nitric Oxide in Renal Vasodilatory and Excretory Effects of Bradykinin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider