Key result
Specific patterns of electrical activity upregulate troponin I expression, with transcriptional regulation dependent on conserved DNA sequence motifs including a slow upstream regulatory element.
Population
Transgenic mice and Sol8 myotubes
Design
Preclinical
Authors
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Hypothesis-generating for activity-dependent troponin regulation in muscle; leaves open translation to human cardiac or skeletal therapies.
The linear arrangement of DNA sequence motifs is conserved in the regulatory elements of troponin I slow and fast genes, requiring multiple protein-DNA complexes for enhancer function.
Calvo et al. (1996) studied Muscle plasticity. Electrical activity vs. Denervation was evaluated on Troponin I (TnI) gene expression and transcriptional regulation. Specific patterns of electrical activity upregulate troponin I expression, with transcriptional regulation dependent on conserved DNA sequence motifs including a slow upstream regulatory element.
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