Key result
Autosomal ancestry proportions show no association with early cardiovascular disease markers in type 1 diabetes.
Why the study?
Patients with type 1 diabetes have an increased risk of cardiovascular disease, prompting investigation into early markers of cardiovascular disease associated with clinical data and autosomal ancestry in an admixed population.
Does autosomal ancestry influence the prevalence of early cardiovascular disease markers in patients with type 1 diabetes?
Cross-Sectional (n=99)
No
Does autosomal ancestry influence the prevalence of early cardiovascular disease markers in patients with type 1 diabetes?
Ankle-brachial index is a useful tool for early detection of cardiovascular risk in young patients with type 1 diabetes, while genetic ancestry does not appear to significantly impact early CVD markers in this population.
Answers are grounded in this paper and cite their sources.
ABI screening merits consideration in young T1D regardless of ancestry; cross-sectional data leaves open longitudinal validation and broader applicability.
Patients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. This study investigates early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. A cross-sectional study was conducted with 99 T1D patients. The mean age of the study sample was 27.6 years and the mean duration of T1D was 14.4 years. The frequencies of abnormalities of the early markers of CVD were 19.6% in the ankle-brachial index (ABI), 4.1% in the coronary artery calcium score (CACS), and 5% in the carotid Doppler. A significant percentage of agreement was observed for the comparison of the frequency of abnormalities between CACS and carotid Doppler (92.2%, p = 0.041). There was no significant association between the level of autosomal ancestry proportions and early markers of CVD. The ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.
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Reis et al. (2022) conducted a cross-sectional in Type 1 Diabetes (n=99). Autosomal ancestry proportions was evaluated on Association of autosomal ancestry proportions with abnormalities in early markers of cardiovascular disease (ABI, CACS, carotid Doppler). In an admixed Brazilian population with type 1 diabetes, there was no significant association between autosomal ancestry proportions and early markers of cardiovascular disease.
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