Key result
In an admixed Brazilian population of young patients with type 1 diabetes, there was no significant relationship between autosomal ancestry proportions and early markers of cardiovascular disease.
Why the study?
Patients with type 1 diabetes have an increased risk of cardiovascular disease, a major cause of death, but associations between early markers of CVD, clinical data, and autosomal ancestry in admixed populations required investigation.
Cross-Sectional (n=99)
No
In young, asymptomatic patients with type 1 diabetes, the ankle-brachial index is a useful and cost-effective tool for early identification of subclinical cardiovascular disease, while autosomal ancestry proportions showed no significant association with early CVD markers.
Answers are grounded in this paper and cite their sources.
ABI may aid early CVD detection in young T1D; leaves open ancestry's influence on subclinical markers in admixed groups.
BackgroundPatients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. The objective of this study was to investigate early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. MethodsA cross-sectional study was conducted with 99 T1D patients. The early markers of CVD included the ankle-brachial index (ABI), coronary artery calcium score (CACS), and carotid Doppler sonography. Demographic, clinical, and serum data were collected. A panel of autosomal informational insertion/deletion ancestry markers was used to estimate the individual proportions of European, African, and Amerindian ancestry.ResultsThe study sample had a mean age of 27.6 years and 14.4 years of duration of T1D. The prevalence of alterations in early CVD markers was: ABI (< 0,9) 19.6%, CACS (> 0 +) 4.1%, and carotid Doppler 5.0%. There was significant agreement between CACS and carotid Doppler, and these were correlated with traditional risk factors for CVD. There was a predominance of European ancestry (47.3%), followed by African (28%) and Ameridian (24.7%). There were no association between early CVD markers and autosomal ancestry proportions.ConclusionThe ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease, and showed agreement with the carotid Doppler. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.
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Reis et al. (2022) conducted a cross-sectional in Type 1 Diabetes (n=99). Autosomal ancestry proportions was evaluated on Association between autosomal ancestry proportions and early markers of cardiovascular disease (ABI, CACS, carotid Doppler). In an admixed Brazilian population of young patients with type 1 diabetes, there was no significant relationship between autosomal ancestry proportions and early markers of cardiovascular disease.
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