Why the study?
To compare traditional CVD risk factors and novel early markers, including arterial stiffness and myocardial structure, between youth with type 1 diabetes and healthy controls.
Do youth with type 1 diabetes exhibit early alterations in myocardial structure and traditional CVD risk factors compared to healthy controls?
Do youth with type 1 diabetes exhibit early alterations in myocardial structure and traditional CVD risk factors compared to healthy controls?
Youth with type 1 diabetes exhibit early adverse alterations in myocardial structure and traditional cardiovascular risk factors by age 14-18, suggesting a need for early preventive strategies.
Answers are grounded in this paper and cite their sources.
Early arterial and myocardial changes in T1D youth merit monitoring; leaves open their prognostic value and need for targeted trials.
Objectives: To compare traditional risk factors for CVD (adiposity, dyslipidemia, hypertension), and novel early markers (arterial stiffness and myocardial structure), between youth with type 1 diabetes (T1D) and healthy controls. Methods: We compared 100 youth with T1D (14-18 yrs) and 97 age- and sex-matched controls. BMI z-scores were computed and percent body fat (%BF) measured by DEXA. Age, sex and height-specific z-scores for blood pressure (BP) were calculated. HbA1c and lipids were measured fasted. Carotid-femoral pulse-wave velocity (Sphygmocor) estimated arterial stiffness. Cardiac magnetic resonance measured left ventricular diastolic myomass, papillary mass and average wall thickness. T-tests, Chi-square and Fisher’s exact determined differences between the groups. Results: There were no differences in ethnicity, sex or pubertal stage across groups. Median T1D duration was 6.1 (IQR=3.3-10.5) yrs; average HbA1c was 8.5% (SD=1.5). Youth with T1D had higher adiposity, modestly higher triglycerides, LDL-c and diastolic BP (albeit in normal range), and increased myomass and average wall thickness, compared with controls (Table). Conclusions: Early alterations in myocardial structure (by 14-18 yrs), along with adverse profiles in traditional risk factors suggest that CVD prevention should be initiated prior to adolescence in pediatric T1D. Disclosure S. Harnois-Leblanc: None. V. McNealis: None. M.G. Friedrich: Board Member; Self; Circle Cardiovascular Imaging Inc.
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Harnois‐Leblanc et al. (2020) studied this question.
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