Vascular and Myocardial Structure and Function in Adolescents with Type 1 Diabetes: The CARDEA Study
Why the study?
Despite heightened risk of CVD among individuals with type 1 diabetes, few studies have investigated CVD development using early markers in adolescence.
Does type 1 diabetes alter cardiovascular risk factors and early markers of CVD in adolescents compared to healthy peers?
Population
100 adolescents with type 1 diabetes and 97 adolescents without diabetes (14-18 years)
Comparison
Adolescents with type 1 diabetes vs adolescents without diabetes
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
Elevated CVD risk factors in T1D adolescents warrant monitoring; cross-sectional data leaves open causal links and sex-specific effects.
Structured PICO
Does type 1 diabetes alter cardiovascular risk factors and early markers of CVD in adolescents compared to healthy peers?
P
Population
197 adolescents (14-18 years), including 100 with type 1 diabetes and 97 without diabetes, recruited at the Sainte-Justine University Hospital Center.
I
Intervention
Type 1 diabetes
C
Comparator
Adolescents without diabetes
O
Outcome
Cardiovascular risk factors (blood pressure and dyslipidemia) and early markers of CVD (arterial stiffness, endothelial function, left ventricular mass, papillary mass, and wall thickness)surrogate
Adolescents with type 1 diabetes exhibit early signs of cardiovascular risk, including higher blood pressure, dyslipidemia, endothelial dysfunction, and altered cardiac structure, highlighting the need for early CVD prevention.
Cite This Study
Harnois‐Leblanc et al. (2023) studied this question.