Key result
Exposure to step changes in end-tidal carbon dioxide and hypoxia during exercise showed the peripheral chemoreflex loop contributes up to 75% of ventilatory drive with a time delay of ~3.5 seconds.
Population
4 human subjects exercising in hypoxia
Design
Other
Authors
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Refines ventilatory control models in hypoxia; leaves open clinical translation pending larger studies.
The peripheral chemoreceptor pathway's effectiveness is enhanced during moderate exercise, contributing significantly to ventilatory drive.
Macfarlane et al. (1992) studied this question. Step changes of end-tidal carbon dioxide and hypoxia was evaluated on Dynamics of the ventilatory responses (contribution, time delays, and time constants of peripheral and central chemoreflex pathways). Exposure to step changes in end-tidal carbon dioxide and hypoxia during exercise showed the peripheral chemoreflex loop contributes up to 75% of ventilatory drive with a time delay of ~3.5 seconds.
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