Why the study?
Does sustained hypoxia alter the ventilatory response to CO2 of the peripheral and central chemoreflex loop in healthy subjects?
Population
10 healthy subjects
Comparison
Exposure to two consecutive periods of isocapnic… vs Prehypoxic state (baseline normoxia)
Design
Other
Authors
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Indicates offset shift drives hypoxic ventilatory decline; hypothesis-generating for clinical hypoxia but should not yet change practice.
Does sustained hypoxia alter the ventilatory response to CO2 of the peripheral and central chemoreflex loop in healthy subjects?
The hypoxic ventilatory decline in humans appears to be due to a change in the off-set of the peripheral chemoreflex loop rather than changes in central or peripheral CO2 sensitivities.
Berkenbosch et al. (1992) studied this question.
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