Why the study?
Does 3 hours of isocapnic hypoxia alter the peripheral chemoreflex ventilatory response to carbon dioxide in healthy volunteers?
Does 3 hours of isocapnic hypoxia alter the peripheral chemoreflex ventilatory response to carbon dioxide in healthy volunteers?
Three hours of isocapnic hypoxia decreases the threshold of the peripheral chemoreflex response to carbon dioxide, suggesting this mechanism drives early ventilatory acclimatisation to hypoxia.
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May inform mechanisms of early ventilatory acclimatisation; hypothesis-generating and requires validation before clinical relevance.
Mahamed et al. (2002) studied this question.
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