Key result
Repeated 20-minute daily exposures to isocapnic hypoxia over 14 days significantly decreased the peripheral chemoreflex threshold from 42 mmHg to 39 mmHg.
Why the study?
Does repeated daily exposure to 20 min of isocapnic hypoxia change respiratory chemoreflex control in volunteers?
Population
7 volunteers (5 male, 2 female)
Comparison
20 min isocapnic hypoxia once daily for 14… vs Air substituted for the hypoxic gas mixture in a…
Design
Pseudorandom crossover design
Follow-up
14 days
Authors
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May modify chemoreflex sensitivity in healthy volunteers; leaves open clinical relevance or safety in disease.
RCT (n=7)
pseudorandom
Does repeated daily exposure to 20 min of isocapnic hypoxia change respiratory chemoreflex control in volunteers?
Repeated daily hypoxic exposures enhance the initial ventilatory response to hypoxia by decreasing the peripheral chemoreflex threshold.
Mahamed et al. (2001) reported an RCT. Isocapnic (eucapnic) hypoxia vs. Air was evaluated on Chemoreflex threshold measured in iso-oxic (hypoxic) modified rebreathing tests. Repeated 20-minute daily exposures to isocapnic hypoxia over 14 days significantly decreased the peripheral chemoreflex threshold from 42 mmHg to 39 mmHg.
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