What question did this study set out to answer?

To determine how selective stimulation of peripheral chemoreceptors influences the biphasic ventilatory response and subsequent ventilatory decline during sustained hypoxia.

September 1, 1989Journal of Applied Physiology

Increased chemoreceptor output and ventilatory response to sustained hypoxia

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Why the study?

Does almitrine alter the ventilatory response to sustained hypoxia in adult humans?

Population

8 adult human subjects

Comparison

Almitrine 75 mg oral administered 2 hours before… vs Placebo administered on a separate day

Design

Other, single-blind

Follow-up

Acute (approx. 3 hours protocol)

Authors

DGDimitrios GeorgopoulosUniversity of Crete SWStuart WalkerGrantham College NAN. R. AnthonisenDartmouth College

Discussion

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Implication

Almitrine augments acute hypoxic ventilation and subsequent decline; extends mechanistic understanding of peripheral chemoreflexes but leaves clinical translation open.

Key Points

To determine how selective stimulation of peripheral chemoreceptors influences the biphasic ventilatory response and subsequent ventilatory decline during sustained hypoxia.
Single-blind, two-day crossover study in 8 adult subjects pretreated with oral almitrine (75 mg) or placebo.
Participants sequentially breathed room air, hyperoxia, and isocapnic hypoxia (25 minutes, arterial oxygen saturation = 80%).
Inspiratory minute ventilation and breathing patterns were recorded during baseline periods and sustained hypoxia.
Early hypoxia increased inspiratory minute ventilation by 14.2 ± 1 L/min with almitrine compared to 4.6 ± 1 L/min with placebo.
Hypoxic ventilatory decline was significantly larger after almitrine pretreatment than after placebo.
Ventilatory decline remained a constant fraction of the acute hypoxic ventilatory response on both study days.

Structured PICO

Does almitrine alter the ventilatory response to sustained hypoxia in adult humans?

Population

8 adult human subjects

Intervention

Almitrine 75 mg oral (po) administered 2 hours before a breathing protocol including 25 minutes of hypoxia (SaO2 = 80%)

Comparator

Placebo administered on a separate day

Outcome

Inspiratory minute ventilation (VI) and breathing patterns measured over specific intervals during room air, O2, and hypoxia exposuresurrogate

Selective stimulation of peripheral chemoreceptors with almitrine significantly increases both the acute ventilatory response to hypoxia and the subsequent hypoxic ventilatory decline.

Cite This Study

Georgopoulos et al. (1989) studied this question.

synapsesocial.com/papers/6a90e785f61bbdbd5ac1a812 https://doi.org/10.1152/jappl.1989.67.3.1157

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Implication

Almitrine augments acute hypoxic ventilation and subsequent decline; extends mechanistic understanding of peripheral chemoreflexes but leaves clinical translation open.

Increased chemoreceptor output and ventilatory response to sustained hypoxia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Increased chemoreceptor output and ventilatory response to sustained hypoxia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider