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November 12, 2013Equine Veterinary Journal

Troponin assays in the assessment of the equine myocardium

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Key result

Human-validated troponin assays used for detecting equine myocardial damage face problematic application due to a lack of veterinary validation, standardized protocols, and reference materials.

Why the study?

How should human troponin assays be used and interpreted in the assessment of the equine myocardium?

Population

Horses (equine myocardium)

Design

Review

Authors

TRTanya RossiUniversity of GuelphWPW. Glen PyleDalhousie UniversityMMM. GRANT MAXIEUniversity of Guelph

Discussion

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Implication

Human troponin assays warrant cautious interpretation in equine myocardial assessment; leaves open species-specific validation and standardization.

Structured PICO

How should human troponin assays be used and interpreted in the assessment of the equine myocardium?

P
Population
Horses (equine myocardium)
E
Exposure
Troponin assays (designed for and clinically validated in human patients)
O
Outcome
Detection and monitoring of myocardial damagesurrogate

The use of human troponin assays in horses requires caution and critical interpretation due to a lack of veterinary-specific validation and standardization.

Limitations

  • Wide diversity of available tests
  • Lack of validation
  • Absence of protocols for their use
  • Lack of standardisation

Cite This Study

Rossi et al. (2013) conducted a review in Myocardial injury in horses. Troponin assays was evaluated. Human-validated troponin assays used for detecting equine myocardial damage face problematic application due to a lack of veterinary validation, standardized protocols, and reference materials.

synapsesocial.com/papers/6a22c902a1bd7ea8dd11db39https://doi.org/10.1111/evj.12209
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Also Consider

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  1. 1Assay Imprecision and 99th-Percentile Reference Value of a High-Sensitivity Cardiac Troponin I Assay2009 · 37 citations
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