Why the study?
Does mycophenolate mofetil reduce kidney injury in mice with ANG II-induced hypertension?
Population
129/SvEv mice with hypertension and kidney disease induced by chronic infusion of ANG II, and splenic…
Comparison
Mycophenolate mofetil (MMF) vs Control (implied, no MMF)
Design
Preclinical
Authors
Loading...
MMF ameliorates renal injury independently of BP in ANG II mice; leaves open translation to human hypertensive nephropathy.
Does mycophenolate mofetil reduce kidney injury in mice with ANG II-induced hypertension?
In a mouse model of ANG II-induced hypertension, immunosuppression with MMF ameliorates kidney injury independently of blood pressure, highlighting the role of ANG II-stimulated lymphocyte responses in renal pathology.
Crowley et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: