Why the study?
Does MMF or candesartan reduce intrarenal ANG II, interstitial inflammation, and cortical vasoconstriction in rats with salt-sensitive hypertension?
Population
Rats exposed to Angiotensin II followed by a high-salt diet to induce salt-sensitive hypertension
Comparison
Mycophenolate mofetil treatment during exogenous… vs Sham controls; rats receiving ANG II without MMF
Design
Preclinical
Authors
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Should not alter clinical practice; extends preclinical data on MMF in ANG II-mediated renal injury.
Does MMF or candesartan reduce intrarenal ANG II, interstitial inflammation, and cortical vasoconstriction in rats with salt-sensitive hypertension?
Cortical vasoconstriction in salt-sensitive hypertension following ANG II exposure is mediated by intrarenal ANG II and related to interstitial inflammation, which can be mitigated by MMF or candesartan.
Franco et al. (2006) studied this question.
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