Key result
Continuous ANG II infusion in rats resulted in sustained elevation of MCP-1 and TGF-beta1 mRNA levels 6 days after withdrawal, suggesting a mechanism for persistent macrophage infiltration.
Population
Male Sprague-Dawley rats maintained on a normal diet
Comparison
Continuous angiotensin II infusion… vs Sham operation
Design
Preclinical
Follow-up
Up to 6 days after cessation of 12-day infusion
Authors
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Residual post-ANG II cytokines in rats may sustain salt sensitivity; leaves open human translation.
Chronic ANG II infusion induces sustained activation of MCP-1 and TGF-beta1 and persistent interstitial macrophage infiltration even after withdrawal, suggesting a mechanism for salt sensitivity in ANG II-dependent hypertension.
Ozawa et al. (2006) studied Hypertension. Continuous ANG II infusion vs. Sham operation was evaluated on Residual cytokines and chemokines (MCP-1 and TGF-beta1) following cessation of ANG II infusion. Continuous ANG II infusion in rats resulted in sustained elevation of MCP-1 and TGF-beta1 mRNA levels 6 days after withdrawal, suggesting a mechanism for persistent macrophage infiltration.
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