December 1, 1998Journal of Hypertension
Genetics of experimental hypertension
Key result
Experimental models of genetic hypertension have identified quantitative trait loci for blood pressure regulation, aiding the understanding of human essential hypertension.
Population
Experimental models of genetic hypertension and human subjects with essential hypertension
Design
Review
Authors
Discussion
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Implication
Should not yet change hypertension practice; leaves open translation of QTLs to human risk prediction or therapy.
Structured PICO
P
Population
Experimental models of genetic hypertension (various rat crosses) and human subjects with essential hypertension
Experimental rat models of genetic hypertension have successfully identified quantitative trait loci for blood pressure regulation, with some loci translating directly to human essential hypertension.
Limitations
- Positional cloning of the causal gene has so far been elusive.
- Positional cloning of the causal gene has so far been elusive
Cite This Study
Dominiczak et al. (1998) conducted a review in Hypertension. Experimental models of genetic hypertension was evaluated. Experimental models of genetic hypertension have identified quantitative trait loci for blood pressure regulation, aiding the understanding of human essential hypertension.