Key result
Elevated BP linked to ~19-fold higher odds of retinopathy and increased renal impairment vs controls.
Why the study?
Prevalence of elevated blood pressure and diabetes mellitus is increasing in sub-Saharan Africa, but data on target organ damage among affected individuals remain scarce.
Does elevated blood pressure and/or diabetes mellitus increase the risk of target organ damage in adults in Lesotho?
Cross-Sectional (n=921)
Single-blind
Yes
Does elevated blood pressure and/or diabetes mellitus increase the risk of target organ damage in adults in Lesotho?
There is a high prevalence of undiagnosed target organ damage among adults with elevated blood pressure and/or diabetes in Lesotho, highlighting the need for community-based screening and prevention.
Answers are grounded in this paper and cite their sources.
Elevated BP links to retinopathy and renal impairment in Lesotho adults; leaves open whether screening improves outcomes in similar settings.
INTRODUCTION: Prevalence of elevated blood pressure (BP) and diabetes mellitus (DM) is increasing in sub-Saharan Africa. Data on target organ damage such as retinopathy, left ventricular hypertrophy (LVH), renal impairment and peripheral neuropathy (PN) among persons with elevated BP and/or DM in sub-Saharan Africa remain scarce. AIM: To determine at community-level the prevalence of retinopathy, LVH, renal impairment, and PN among adults with elevated BP and/or DM, and assess the association of elevated BP and/or DM with target organ damage in Lesotho. METHODS: During a household-based survey, a sub-sample of adults with elevated BP (≥ 140/90 mmHg) and/or DM (glycosylated hemoglobin ≥ 6.5%), as well as comparators (BP < 140/90 mmHg, HbA1c < 6.5%) were screened for retinopathy, LVH, renal impairment, and PN. We used multivariable logistic regression for inferential analysis. RESULTS: Out of 6108 participants screened during the survey, 420 with elevated BP only, 80 with DM only, 61 with elevated BP and DM, and 360 comparators were assessed for target organ damage. Among those with elevated BP, and among those with DM with or without elevated BP, prevalence of retinopathy was 34.6% (89/257) and 14.4% (15/104); renal impairment was 45.0% (156/347) and 42.4% (56/132), respectively. Among those with elevated BP, 2.3% (7/300) and 65.7% (224/341) had LVH and left ventricular concentric remodeling, respectively. PN, only assessed among those with DM, was present in 32.6% (42/129). Elevated BP was associated with increased odds of retinopathy (aOR, 19.13; 95% CI, 8.52-42.94; P < 0.001) and renal impairment (aOR, 1.80; 95% CI, 1.27-2.55; P = 0.001). Presence of both elevated BP and DM was associated with an increased odds of retinopathy (aOR, 16.30; 95%CI, 5.69-46.68; P < 0.001), renal impairment (aOR, 2.55; 95% CI, 1.35-4.81; P = 0.004), and PN (aOR, 2.13; 95% CI, 1.04-4.38; P = 0.040). CONCLUSION: We found a high prevalence of undiagnosed target organ damage among adults with elevated BP and/or DM during community-based screening. These findings emphasize the importance of regular prevention and screening activities in this setting.
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Firima et al. (2023) conducted a cross-sectional in Elevated blood pressure and/or diabetes mellitus (n=921). Elevated blood pressure vs. No elevated blood pressure or diabetes mellitus was evaluated on Retinopathy (aOR 19.13, 95% CI 8.52-42.94, p=<0.001). Elevated blood pressure was associated with increased odds of retinopathy and renal impairment compared to individuals without elevated blood pressure or diabetes.
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