Key result
A subset of subjects with low renin essential hypertension and high delta PA/delta PRA ratios exhibited an abnormally enhanced aldosterone responsiveness to angiotensin II during low sodium intake.
Why the study?
Does aldosterone responsiveness to angiotensin II differ between subjects with low renin essential hypertension and normotensive subjects after sodium restriction?
Observational (n=30)
Does aldosterone responsiveness to angiotensin II differ between subjects with low renin essential hypertension and normotensive subjects after sodium restriction?
A subset of patients with low renin essential hypertension demonstrates an abnormally enhanced aldosterone response to angiotensin II under low sodium conditions.
May identify an aldosterone-hyperresponsive subset in low-renin hypertension; hypothesis-generating and should not yet change practice.
Plasma aldosterone (PA) responses to sodium restriction (25 mEq sodium/day for 4 days) and to graded angiotensin II (AII) infusions (2, 4 and 8 ng/kg/min each for 30 min) during a low sodium intake were studied in 14 subjects with low renin essential hypertension (LREH) versus 16 normotensive subjects. The PA response to sodium restriction in relation to changes in plasma renin activity (PRA) was estimated by the ratio of PA increment to PRA increment after sodium restriction (delta PA/delta PRA). In 8 of 14 LREH subjects, whose delta PA/delta PRA ratios were normal, the PA responses to the graded AII doses were similar to those in the normotensive subjects. However, in the remaining 6 LREH subjects whose delta PA/delta PRA ratios were high the PA responses to the graded AII doses were greater. Apparently some LREH subjects, whose delta PA/delta PRA ratios after sodium restriction were high, have an abnormally enhanced aldosterone responsiveness to AII under the condition of low sodium intake.
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Takeda et al. (1982) conducted an observational in Low renin essential hypertension (n=30). Sodium restriction and graded angiotensin II infusions vs. Normotensive subjects was evaluated on Plasma aldosterone response to sodium restriction and graded angiotensin II infusions. A subset of subjects with low renin essential hypertension and high delta PA/delta PRA ratios exhibited an abnormally enhanced aldosterone responsiveness to angiotensin II during low sodium intake.
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