Why the study?
Does the plasma aldosterone response to sodium restriction and angiotensin II infusion differ between elderly subjects with mild essential hypertension and normotensive controls?
Population
25 elderly subjects, including 15 with mild essential hypertension and 10 normotensive subjects.
Comparison
Sodium restriction followed by graded infusions… vs Normotensive elderly subjects undergoing the…
Design
Cohort
Follow-up
4 days
Authors
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May characterize a low-renin hypertensive subset with heightened aldosterone sensitivity; hypothesis-generating for targeted interventions in larger trials.
Does the plasma aldosterone response to sodium restriction and angiotensin II infusion differ between elderly subjects with mild essential hypertension and normotensive controls?
A subset of elderly patients with essential hypertension and subnormal renin response to sodium restriction exhibit an abnormally enhanced adrenal aldosterone response to angiotensin II.
Morimoto et al. (1981) studied this question.
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