Key result
Infusion of the nitric oxide synthase inhibitor L-NMMA significantly reduced leg glucose uptake by 48% compared with saline control during dynamic exercise (P<0.05).
Why the study?
Does nitric oxide synthase inhibition with L-NMMA reduce leg glucose uptake during dynamic exercise in healthy men?
RCT (n=7)
blinded
randomized crossover
Does nitric oxide synthase inhibition with L-NMMA reduce leg glucose uptake during dynamic exercise in healthy men?
Effect estimate: 48 +/- 12% lower
p-value: p=<0.05
Nitric oxide production contributes substantially to exercise-mediated skeletal muscle glucose uptake in humans independent of skeletal muscle blood flow.
Authors
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NO supports substantial exercise glucose uptake independent of flow; extends mechanistic understanding for metabolic therapies.
Bradley et al. (1999) conducted an RCT in healthy (n=7). L-NMMA (N(G)-monomethyl-L-arginine) vs. saline was evaluated on leg glucose uptake (48 +/- 12% lower, p=<0.05). Infusion of the nitric oxide synthase inhibitor L-NMMA significantly reduced leg glucose uptake by 48% compared with saline control during dynamic exercise (P<0.05).
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