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August 1, 2002Diabetes

Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects

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Why the study?

Does nitric oxide synthase inhibition with L-NMMA reduce leg glucose uptake during exercise more in individuals with type 2 diabetes than in healthy controls?

Population

18 men

Comparison

N-monomethyl-L-arginine total dose 6 mg/kg… vs Placebo administered into the femoral artery for…

Design

RCT, counterbalanced crossover design, blinded

Follow-up

acute (during 25-min exercise bout)

Authors

BKBronwyn A. KingwellPreventive CardiologyMFMelissa F. FormosaBaker Heart and Diabetes InstituteMMM. MuhlmannSir Charles Gairdner Hospital

Discussion

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Implication

Greater nitric oxide dependence for exercise glucose uptake in type 2 diabetes; extends mechanistic understanding to diabetic populations.

Structured PICO

Does nitric oxide synthase inhibition with L-NMMA reduce leg glucose uptake during exercise more in individuals with type 2 diabetes than in healthy controls?

P
Population
18 men (9 with type 2 diabetes and 9 healthy controls matched for age, sex, peak pulmonary oxygen uptake, and weight)
I
Intervention
N(G)-monomethyl-L-arginine (L-NMMA) total dose 6 mg/kg administered into the femoral artery for the final 15 min of a 25-min cycling exercise bout
C
Comparator
Placebo administered into the femoral artery for the final 15 min of a 25-min cycling exercise bout
O
Outcome
Leg glucose uptake (calculated as the product of leg blood flow and femoral arteriovenous glucose difference)surrogate

Nitric oxide synthase inhibition causes a greater reduction in exercise-induced leg glucose uptake in individuals with type 2 diabetes compared to controls, suggesting a greater reliance on nitric oxide for glucose uptake in this population.

Cite This Study

Kingwell et al. (2002) studied this question.

synapsesocial.com/papers/6a760108d5b06e2c1e6138e9https://doi.org/10.2337/diabetes.51.8.2572
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.1999 · 171 citations
  2. 2Systemic Nitric Oxide Synthase Inhibition Increases Insulin Sensitivity in Man1998 · 18 citations
  3. 3Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice2015 · 19 citations
  4. 4Nitric oxide modulation of renal and cardiac hemodynamics in type 2 diabetes2002 · 14 citations
  5. 5Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent1998 · 287 citations