Key result
Systemic infusion of L-NMMA decreased cardiac index similarly across groups, but its effect on reducing glomerular filtration rate was impaired in type 2 diabetic patients compared to controls.
Why the study?
Does systemic infusion of L-NMMA alter cardiovascular and renal hemodynamics differently in type 2 diabetic patients compared to controls?
Population
17 subjects with mild arterial hypertension, including 6 type 2 diabetic patients with microalbuminuria, 6…
Comparison
Systemic infusion of the nitric oxide synthase… vs Control subjects with mild arterial hypertension.
Design
Other
Authors
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Impaired renal response to L-NMMA in type 2 diabetes suggests endothelial dysfunction; leaves open whether microalbuminuria adds specific risk.
Does systemic infusion of L-NMMA alter cardiovascular and renal hemodynamics differently in type 2 diabetic patients compared to controls?
Glomerular nitric oxide homeostasis is altered in type 2 diabetes, and its modulation of glomerular hemodynamics appears independent of NO-regulated cardiac output.
Vestra et al. (2002) studied Type 2 diabetes (n=17). NG-monomethyl-l-arginine (L-NMMA) vs. Control subjects was evaluated on Cardiovascular and renal hemodynamics (cardiac index, glomerular filtration rate, filtration fraction). Systemic infusion of L-NMMA decreased cardiac index similarly across groups, but its effect on reducing glomerular filtration rate was impaired in type 2 diabetic patients compared to controls.
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