Why the study?
Does systemic nitric oxide synthase inhibition with NG-monomethyl L-arginine improve whole-body glucose uptake in healthy male subjects?
Population
16 healthy male subjects
Comparison
NG-monomethyl L-arginine infusion (3 mg h-1 kg-1) vs Placebo
Design
RCT, randomized crossover, double-blind
Authors
Loading...
Challenges the hypothesis that nitric oxide inhibition impairs insulin sensitivity; extends metabolic research on endothelial NO in healthy subjects.
Does systemic nitric oxide synthase inhibition with NG-monomethyl L-arginine improve whole-body glucose uptake in healthy male subjects?
Systemic inhibition of nitric oxide synthesis with NG-monomethyl L-arginine increases whole-body glucose uptake and calf blood flow in healthy men, challenging the hypothesis that endothelial nitric oxide inhibition decreases insulin sensitivity.
Butler et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: