What question did this study set out to answer?

This research aims to understand how angiotensin affects the sympathetic nervous system and its role in renal hypertension.

May 1, 1963Circulation ResearchOpen Access

Renal Pressor System and Neurogenic Control of Arterial Pressure

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Design

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Authors

JMJ. W. McCubbinInternational Academy of Business and New Technologies IPIrvine H. PagePennine Acute Hospitals NHS Trust

Discussion

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Implication

Angiotensin-sympathoexcitation may underlie neurogenic renal hypertension; leaves open relevance to current RAAS inhibitor strategies.

Key Points

This research aims to understand how angiotensin affects the sympathetic nervous system and its role in renal hypertension.
Examined the effects of angiotensin on sympathetic nervous system responses
Assessed changes in response to tyramine in acute and chronic renal hypertension
Analyzed neurogenic vasomotor activity and carotid sinus mechanisms.
Increased response to tyramine in both acute and chronic renal hypertension, indicating an ongoing effect of low-level angiotensin.
Angiotensin enhances the normal neurogenic vasomotor activity, contributing significantly to chronic renal hypertension.
Changes in the carotid sinus buffer mechanism suggest altered thresholds and response ranges.

Structured PICO

Intervention

Angiotensin

Outcome

Sympathetic nervous system response to endogenous norepinephrine releasesurrogate

Angiotensin's enhancement of sympathetic nervous system activity may be a major mechanism underlying the neurogenic component of chronic renal hypertension.

Cite This Study

McCubbin et al. (1963) studied this question.

synapsesocial.com/papers/6a22da913a78129ded665b8f https://doi.org/10.1161/01.res.12.5.553

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Renal Pressor System and Neurogenic Control of Arterial Pressure

Discussion

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Implication

Key Points

Structured PICO

Cite This Study

Renal Pressor System and Neurogenic Control of Arterial Pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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