Ca2+-Activated Chloride Channels and Phospholipid Scramblases

Figures

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  Figure 1. TMEM16 gene family. Phylogenetic tree showing the TMEM16 gene family in humans. Some members are ion channels, while some are phospholipid scramblases. At least TMEM16E and 16F are both scramblases and ion channels. Mutation or mis-regulation of some TMEM16 proteins cause human diseases. Scale bar, 0.1 nucleotide substitutions per site.